From any point of departure, head to Milan and then follow the signs for the A9 motorway, connecting Milan to Switzerland, direction Como - Chiasso
Take the exit LAGO DI COMO (last exit before the Swiss border coming from Milan; first exit after the Swiss border coming from Switzerland).
After about 1 km you’ll find a roundabout, take the 3rd exit follow the sign for MENAGGIO.
Drive along the panoramic road (Strada Statale Regina SS340) along the shore of the lake for about 25 km.
You’ll see some orange signs along the road indicating the distance to the Grand Hotel Tremezzo. Once you see the TREMEZZO town sign, you’ll find the Grand Hotel Tremezzo on your left after about 800 mt.